KCNH1 and non-small cell lung carcinoma: For example, astemizole is a second-generation antihistamine that blocks some K+ channels, including KCNH1 and KCNH2 [73], and reduces the proliferation of HPV+ cervical cancer (CC) cells [74], while in non-small cell lung cancer (NSCLC) cell lines, this drug did not prevent the epithelial-to-mesenchymal transition (EMT) despite the fact that KCNH1 gene and protein expression were up-regulated during EMT [72].