AKT1 and cancer: In CC HPV+ cell lines, the potassium voltage-gated channel subfamily C member 4 (KCNC4 or Kv3.4) and the AKT pathway have been shown to regulate vimentin expression, and the use of blood depressing substance II (BDS-II) as a channel blocker (Table 2) decreases vimentin expression and cancer cell migration [56].