KCNMA1 and cardiac rhythm disease: The up-regulation of the calcium-activated potassium channel, subfamily M, and alpha member 1 (KCNMA1 or KCa1.1) in combination with verapamil (a drug used in the treatment of cardiac arrhythmias and the inhibition of transmembrane Ca2+ flux) [180] potentiates the cytotoxic effect of cisplatin against ESCC (Table 2) [130].