Moreover, a comparison of SVIP expression in different prostate cell lines revealed that SVIP is highly expressed in androgen-dependent prostate cancer cells (LNCAP, 22RV1) but not in androgen-independent cell lines (PC3, DU145) or non-tumorigenic prostate cell lines, including normal prostate epithelial cell lines (RWPE1) and benign prostatic hyperplasia epithelial cell lines (BPH1) [16]. Here, SVIP is linked to benign prostatic hyperplasia.