IL6 and Decreased total B cell count: Therefore, all these aspects are directly linked with immune dysregulation, as two main features occur in critically ill patients, pro-inflammatory cytokines (especially IL-6) overproduction by monocytes and dysregulation of lymphocytes characterized by CD4 lymphopenia and, subsequently, B-cell lymphopenia in addition to activating the inflammatory response and promoting OS [9,39,40,41].