In the same perspective, the prospective study by Alserawan et al. [223], which analyzed patients with COVID-19, was able to show that patients with low levels of the saturated oxygen/fraction of inspired oxygen (SpO2/FiO2) ≤ 400 had higher levels of GDF15, IL-6, D-dimer, and CRP. The gene discussed is GDF15; the disease is COVID-19.