We speculate NSUN6 can inhibit the malignant progression of lung adenocarcinoma in two ways: (1) Inhibiting the malignant phenotypes of tumour cells through other pathways; (2) Inhibiting the malignant progression of lung adenocarcinoma by inhibiting macrophages from interfering with the immunosuppressive microenvironment. Here, NSUN6 is linked to lung adenocarcinoma.