IHC staining verified a significant decrease in YY1, a significant decrease in vimentin expression and a significant increase in E-cadherin expression in tumor tissues of the HMSN-ISO@ProA-PD-L1 Ab treated group (Fig. 8H), indicating that HMSN-ISO@ProA-PD-L1 Ab played a role in inhibiting EMT of tumors. The gene discussed is VIM; the disease is neoplasm.