Based on the above background, we designed dual-functional mesoporous silica nanoparticles loading with ISO and anti-PD-L1 monoclonal antibody (HMSN-ISO@ProA-PD-L1 Ab), which can target tumor cells, inhibit YY1 mediated tumor progression, and improve the killing effect of T-cells on tumors by inhibiting the PD-1/PD-L1 signaling pathway (Fig. 1). This evidence concerns the gene CD274 and neoplasm.