T-cells derived from the spleen of wild-type C57BL/6 mice were co-cultured with Hepa1-6 cells (2:100), and the proliferation capacity of HMSN-ISO@ProA-PD-L1 Ab treated co-cultured tumor cells was significantly weaker than the co-cultured tumor cells of the control group (Fig. 7J). This evidence concerns the gene CD274 and neoplasm.