The tumor growth rate of mice during treatment was PBS control group > ISO group > PD-L1 group > HMSN-ISO@ProA-PD-L1 Ab group, indicating that HMSN-ISO@ProA-PD-L1 Ab can effectively inhibited the growth of Hepa1-6 tumors (Fig. 8B and C). The gene discussed is CD274; the disease is neoplasm.