IL10 and systemic lupus erythematosus: Any depletion of IL-1Ra or IL-10 during ultrafiltration could be deleterious and potentially be modified by supplementation of these mediators, which have been used clinically in multiple trials investigating effects in chronic inflammatory diseases such as Crohn’s disease, ulcerative colitis, rheumatoid arthritis, and systemic lupus erythematosus [34–36].