HIF-1α, AGEs, AKT Serine/Threonine Kinase 1 (AKT), VEGF, Guanosine 3′,5′-cyclic monophosphate-Protein Kinase CGMP-Dependent 1 (cGMP-PKG/PRKG1), TLR, Nf-KB, mitogen-activated protein kinase (MAPK), mechanistic target of rapamycin kinase (mTOR), and TNF signaling pathways were associated with sepsis development among the significantly enriched KEGG pathways. Here, HIF1A is linked to Sepsis.