Our data (G4, sepsis) conflicts with human data suggesting that Nrf2 is upregulated in pediatric sepsis [64] although trained animals seemed to preserve Nrf2 expression when exposed to CLP (G6).The Keap1-Nrf2 system is a key cellular defense mechanism that protects cells from metabolic and oxidative stress, and counteracts hepatic oxidative stress [65]. Here, KEAP1 is linked to Sepsis.