Comparison of these signatures between normal and tumor samples indicated that HMGB3, E2F1, PLAU, ATAD2, and KIAA1549L were highly expressed in tumor tissues, while RIMS3, CADM2, FYCO1, TGFBR2, KLHL15, SNCG, HHIP, CYBRD1, and CELF2 were downregulated (Fig. 6B). This evidence concerns the gene RIMS3 and neoplasm.