In vivo, mice deletion of endothelial KATP subunit Kir6.1 impaired vasorelaxation during hypoxia, became more hypertensive in a high-salt diet, suggesting regulation of endothelial KATP is an important target for treatment of development of hypertension and atherosclerosis [270, 271]. The gene discussed is KCNJ8; the disease is hypertensive disorder.