NOS3 and endothelial dysfunction: Akap1 knockout significantly increased ROS production and apoptosis, reduced Akt/eNOS phosphorylation, capillary-like network formation, migration and proliferation in ECs, impaired hindlimb blood flow and skeletal muscle capillary density after femoral artery ligation in mice [243], suggesting that Akap1 may serve as a novel target for improving endothelial dysfunction and treating vascular diseases.