In this study samples were divided into groups based allergen sensitization status (allergic, non-allergic asthma), vitamin D content (deficiency < 20 ng/ml, insufficiency 20–30 ng/ml, normal amount 30–50 ng/ml) and assessed the type of VDR gene polymorphisms and VDBP gene polymorphisms in asthma subjects and control group. The gene discussed is GC; the disease is asthma.