Based on these findings, Chen et al. concluded that the overexpression and subsequent secretion of ELNAT1 from bladder cancer cells promotes tumor lymphangiogenesis and lymphatic metastasis through the upregulation of SOX18, which in turn leads to the aberrant activation of the PROX1-driven lymphatic transcriptional program [187]. The gene discussed is PROX1; the disease is urinary bladder carcinoma.