Thus, BCYRN1 simultaneously increases both VEGFR-3 expression in LECs and VEGF-C secretion from bladder cancer cells, creating a feedforward loop that promotes tumor lymphangiogenesis and LN metastasis in bladder cancer through amplified VEGF‐C/VEGFR-3 signaling [106]. This evidence concerns the gene FLT4 and urinary bladder carcinoma.