PROX1 and neoplasm: The exosomes are subsequently internalized by LECs, promoting tumor-associated lymphangiogenesis and lymphatic metastasis through an epigenetic mechanism upregulating the transcription of PROX1. The mechanism involves the formation of a DNA-RNA triplex between LNMAT2 and the PROX1 promoter, thereby recruiting the LNMAT2-tethered HNRNPA2B1 to the promoter region and increasing its H3K4 trimethylation (H3K4me3) [180].