Given these results, we tested the functional importance of FLCN in DC-mediated adaptive and anti-tumour immunity by generating FlcnΔDC (via Cd11ccre) mice and mixed bone marrow chimeras, which showed cell-intrinsic decreases in cDC2 but not cDC1 number in spleen under steady state conditions (Extended Data Fig. 7c–e). This evidence concerns the gene MPPE1 and neoplasm.