The role of members of the heterogeneous nuclear ribonucleoproteins in NDDs (HNRNPH1, HNRNPH2, HNRNPK, HNRNPR and HNRNPU) and cancer (HNRNPA1, HNRNPA2B1, HNRNPC, HNRNPD, HNRNPF, HNRNPK, HNRNPR, and HNRNPU) has been the subject of recent investigations but the relationships between the individual function of disease-associated HNRNPs and the mechanisms of relevant disorders is not well defined [5, 33]. This evidence concerns the gene HNRNPH1 and cancer.