The expression of TPX2, TOP2A and MYBL23 was significantly higher in cancer tissues than in paracancerous tissues, but SFTPB was lower in cancer tissues (Supplementary Fig. 3A–D), and that TPX2, TOP2A and MYBL23 high expression groups had poorer OS prognosis, while SFTPB high expression group had better OS (p < 0.05, Supplementary Fig. 3E–H). The gene discussed is TOP2A; the disease is cancer.