TOP2A and non-small cell lung carcinoma: On this basis, we further analyzed the correlation between the expression of TOP2A and Wnt3a and the presence of VM ducts in NSCLC, and found that the presence of VM ducts was observed in approximately 48% and 57% of NSCLC with positive expression of TOP2A and Wnt3a, respectively, while only 19% and 8% of tumors with negative expression of TOP2A and Wnt3a, respectively, could be observed.