TOP2A and non-small cell lung carcinoma: To investigate the biological function of TOP2A in non-small cell lung cancer, we first constructed NSCLC cell lines with stable high expression of TOP2A in A549 and H1299 cells using a lentiviral vector carrying the full-length gene of TOP2A, and established TOP2A-silenced cell lines in A549 and H1299 cells using two specific siRNAs.