The analysis revealed that age, blood culture, laboratory findings including C-reactive protein, procalcitonin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, total bilirubin, blood urea nitrogen (BUN), creatinine, lymphocyte, neutrophil-to-lymphocyte ratio (NLR), platelet, prothrombin time, and d-dimer, as well as radiological findings such as septations within the abscess, rim enhancement, internal gas bubble, and pleural effusion were significantly associated with sepsis in the derivation cohort. This evidence concerns the gene F2 and Pleural effusion.