ZMPSTE24 and Hutchinson-Gilford progeria syndrome: HGPS is a human progeroid syndrome and is considered the ‘Rosetta Stone’ for studying the mechanisms of aging.37 It is worth noting that HGPS exhibits minimal defects in the nervous system and immune system, and our current model may only partially represent the multifactorial process of normal aging.38 However, our conditional premature aging model could be a useful tool to study interorgan homeostasis, for example, how aged skeletons affect other tissues and organs.