Furthermore, Gal-9 has been reported to drive self-renewal of AML stem cells and leukemic progression [46], although this effect was observed at a concentration of 500 pg/ml Gal-9, which is 2 × 104 times lower than the 300 nM we used in our study and that eliminated the fast-majority of CD34+ AML stem cells. This evidence concerns the gene CD34 and acute myeloid leukemia.