In the last 20 years, several research groups suggested an interplay between STAT3 and HIF1: for instance, Gray and collaborators in 2005 demonstrated that the expression of Vegfa in pancreatic and prostate carcinomas depends on HIF1α, STAT3, CBP/p300 and Ref-1/APE [80] and this result was further investigated by Oh and collaborators [81], who showed that STAT3 and HIF1α bind the Vegfa promoter [81]. This evidence concerns the gene EP300 and prostate carcinoma.