In line with observations from human KRAS mutant cell lines, Cre-mediated in vitro knock-out of Uhrf1 in UKP cells decreased colony growth in 2D and 3D compared to the empty adenovirus control (Supplementary Fig. 6g), further supporting a critical role for UHRF1 in KRAS-driven lung cancer. Here, KRAS is linked to lung carcinoma.