UHRF1 and lung cancer: While UHRF1 expression is generally thought to be regulated in a cell cycle-dependent manner, immunofluorescence imaging of tumors from KP mouse lungs revealed the presence of Uhrf1 in cells at different stages of the cell cycle, including G1 and G0 (Supplementary Fig. 6c, d), which suggests a deregulation of its cell cycle-dependent expression in lung cancer.