Comparison between TSGs significantly upregulated after UHRF1 loss and TSGs significantly hypomethylated in UHRF1-depleted cells identified 80 genes in common (Fig. 4f and Supplementary Data 8) including several tumor suppressor genes frequently mutated in human cancers (PTEN, DLC1, CUX1, DUSP22), negative regulators of pro-tumorigenic WNT/β-catenin pathway (FHL1, MCC, AXIN2, WNT7A, CDH13, RASSF8), apoptosis-activators (HIPK2, CD82, GAS1), and negative regulators of mTORC1 signaling (TSC1, TMEM127). This evidence concerns the gene DUSP22 and cancer.