Comparison between TSGs significantly upregulated after UHRF1 loss and TSGs significantly hypomethylated in UHRF1-depleted cells identified 80 genes in common (Fig. 4f and Supplementary Data 8) including several tumor suppressor genes frequently mutated in human cancers (PTEN, DLC1, CUX1, DUSP22), negative regulators of pro-tumorigenic WNT/β-catenin pathway (FHL1, MCC, AXIN2, WNT7A, CDH13, RASSF8), apoptosis-activators (HIPK2, CD82, GAS1), and negative regulators of mTORC1 signaling (TSC1, TMEM127). The gene discussed is HIPK2; the disease is cancer.