Surprisingly, infection of another TLR-null model, through deletion of genes for TLR237, TLR438 and a missense mutation of Unc93b39 (TKO), showed EFRs similar to WT controls (Fig. 4a) along with nominal passive protective capacity (Fig. 4d), despite slight reductions in CD138 + EF PBs at 7 dpi (Fig. 4a). The gene discussed is SDC1; the disease is infection.