We suppose that early postnatal tumor formation in hGFAP-cre::CrebbpFl/Fl::lsl-MYCN mice might be influenced by onset of olfactory experience soon before, and/or by structural and functional disturbances of OB neurons related to CREBBP loss, given that growing evidence indicates neuronal activity to influence tumorigenesis in brain and other tissues [10]. This evidence concerns the gene CREBBP and neoplasm.