Survival of hGFAP-cre::CrebbpFl/Fl::lsl-MYCN mice was significantly reduced (approximately 80% within 8 months) compared to the control group (Fig. 1B, SFig. 1A), as those mice had to be sacrificed due to abnormalities in their fur and (brain) tumor-related symptoms (gait abnormality, unwillingness to move, hunched posture, weight loss). This evidence concerns the gene HGFAC and neoplasm.