hGFAP-cre::CrebbpFl/Fl::lsl-MYCN mice can serve as a model to unravel pathogenetic mechanisms in brain tumors with simultaneous aberrations of CREBBP and MYCN, such as exemplifying broad dysregulation of gene expression by concurrent deviations of a chromatin modifier and global transcriptional regulator and a member of the MYC family. Here, HGFAC is linked to brain neoplasm.