METTL3 and cancer: It has been shown to promote glycolysis by binding to the 3′ untranslated region (3′UTR) of Hk2 mRNA and stabilizing Hk2 mRNA in cancers.[31, 32] We examined whether Igf2bp2 is involved in beige fat glycolytic functionality by recognizing mRNAs modified by Mettl3.