IGF2BP1 and cancer: Aside from its role in mRNA stability, Mettl3 also regulate target gene translation by recruiting RBPs such as Ythdf1, Ythdf3, and Igf2bp1/2/3.[16, 53, 54] For example, a recent study reported that Mettl3 enhanced translation elongation of Pdk4 via YTHDF1/eEF‐2 complex and promote glycolysis in cancer cells.[47] In the present study, we found that Mettl3 depletion in beige fat blunted the glycolytic gene mRNA level.