Two animal models of Fto fat‐specific knockout mice via Adiponectin‐Cre system were reported, both showed impaired lipolysis and white fat browning, while Fto adipose ablation in one model promoted obesity, and the other model had reduced risk for obesity, suggesting the complexity of m6A regulation in obesity[40] and highlighted the specificity, timing and efficiency of gene knockout or knockdown in adipose tissues may contribute to different systemic energy homeostasis. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.