PDK4 and cancer: This enhanced Pdk4 mRNA stability and translational elongation, respectively, and eventually increased cancer cell glycolysis and tumor growth in a m6A dependent manner.[47] Interestingly, recent studies have proposed that BAT activation by cold stimulation consumed substantial blood glucose, thus competed for glucose availability to cancer cells and inhibited tumor growth.[26] In the present study, we found that Mettl3 is indispensable in cold‐induced beige fat activation.