Of nine genes down-regulated by NR2F6 loss, NACC1 and FKBP10 were negatively correlated with the IFN-γ signature (Fig. 4D), while high NACC1 and FKBP10 expression was associated with poor overall survival (Fig. 4E), patterns seen upon tumor-intrinsic NR2F6 inactivation. The gene discussed is NACC1; the disease is neoplasm.