NR2F6 and melanoma: While a role for FKBP10 in regulating tumor immunity has not been reported, FKBP10 functions in collagen biogenesis, which likely affects TIL function, suggesting that remodeling of the extracellular matrix after FKBP10 down-regulation in NR2F6 KO melanoma may govern the degree and effectiveness of antitumor immunity (49–51).