CD8A and neoplasm: Of interest is the observation that while NR2F6 KD effectively induced immune cell infiltration, primarily by CD8+ T cells, which limited tumor growth, NR2F6 OE did not enhance tumor growth, suggesting either that additional cofactors are needed for NR2F6 function or that tumor-intrinsic NR2F6 activity depends on the availability of tumor-extrinsic factors.