Notably, CD8+ T cell depletion did not fully rescue the growth of NR2F6 KO tumors to the degree seen in control NR2F6 WT tumors, suggesting that increased antitumor immunity seen in NR2F6-deficient melanoma is predominantly, but not solely, mediated by tumor-infiltrating CD8+ T cells. Here, NR2F6 is linked to melanoma.