Because the M-current is a powerful stabilizer of the membrane potential, controlling subthreshold activity and synaptic responses, abnormal function of neuronal KCNQ channels have been associated with diseases related to hyperexcitability: a loss of just 25% of KCNQ2 or KCNQ3 channels are the cause of benign familial neonatal seizures [36,37]. This evidence concerns the gene KCNQ2 and Benign familial neonatal seizures.