DDX5 and cancer: Dysregulated expression of β-catenin has been reported in many cancers including OS.37,38 A previous study reported that DDX5 can active β-catenin via promoting the nuclear translocation of β-catenin.14 Another study demonstrated DDX5 upregulated β-catenin and further prompted cancer metastasis.17 Consistently, our study indicated that the downregulation of DDX5 could reduce the protein level of β-catenin and consequently inhibit EMT process.