Interestingly, Chen et al. reported that the upregulation of DDX5 in OS is associated with poor survival.18 Previous studies have suggested vital roles of DDX5 in regulating the metastasis in types of cancer including OS.18,35 Accordingly, our results demonstrated that DDX5 is a target protein of VAMP8 mediating OS cell migration. The gene discussed is VAMP8; the disease is cancer.