In yeast, there are 25 members of SNAREs, while in humans there are 36 members.6,7 SNAREs proteins primarily regulate the docking of the particles and vesicles to target membranes, as well as membrane fusion, which is essential for various biological processes, including viral infection, cell fertilization, intracellular transport and neurotransmitter release.8 Vesicle associated membrane protein 8 (VAMP8) is a v-SNAREs involved in the membrane fusion steps of various endosomes and secretions.9,10 Previous studies suggested that VAMP8 acts key roles in regulating cancer progression. The gene discussed is VAMP8; the disease is cancer.