BCAT1 and breast cancer: For example, in kidney, there was reduced abundance of BCAT1, which promotes mitochondrial biogenesis and ATP production and has been shown to promote breast cancer formation when knocked down,21 and REN1, which has been shown to play a role in modulating vascular tone and tubular function in the kidney.22 For sex effects, we detected 1,006 proteins with consistent differences between sexes across tissues and 2,565 proteins with tissue specificity.