DONSON, XIST, AC018607.1, MALAT1, GOLGA8A, AC005224.3, AC003684.1, VSTM2A, LINC02280, and CDHR2 were under-expressed in exosomes from liver cancer patients, and RPS4Y1, HIST2H2AA3, APOC3, ORM1, APOA2, APOH, HRG, FGB, FGG, FGA were highly expressed in the exosomes of HCC patients (Fig. 1B). The gene discussed is ORM1; the disease is liver cancer.