Moreover, RAP2B is already found to be implicated in numerous biological processes such as platelet activation, autophagy, and signal transduction (Canobbio et al. 2008; Mansilla Pareja et al. 2019; Gao et al. 2021), and its association with proliferation, migration, and invasion has been reported in various cancers such as breast cancer, cervical cancer and bladder cancer (Staalesen et al. 2004; Li et al. 2018; Zhang et al. 2016). This evidence concerns the gene RAP2B and cancer.