TNFSF11 and periodontitis: To gain insight into the events underlying the P. gingivalis mechanisms of periodontitis, we constructed a periodontitis mouse model (WT C57BL/6) and evaluated the ROS levels of gingival cells, gingipain (RgpA, KGP) expression, CEJ-ABC distance, cGAS and STING expression, proinflammatory cytokine secretion, and RANKL mRNA expression (Figure 1A).