STING1 and periodontitis: To evaluate whether the STING gene could affect P. gingivalis infection-induced type I IFN gene expression, we constructed a periodontitis model in StingGt mice and then compared the pathological changes, proinflammatory cytokine activity, macrophage polarization and bone resorption between StingGt mice and WT C57BL/6 periodontitis mice (4 mice per group; Figure 5A).