A recent RNA-seq analysis of AD patients reported that ferroptosis related genes, such as GPX4 and glutathione synthase (GSS), were downregulated at early AD and upregulated at late AD, suggesting that neuronal cells gradually compensate ferroptotic cell death by increasing antioxidant proteins with the progression of AD (Majerníková et al., 2021) (Figure 7). The gene discussed is GSS; the disease is Alzheimer disease.