MAPT and Alzheimer disease: Senescent neurons and glia cells were found to be linked with AD and PD (Turnquist et al., 2016; Bussian et al., 2018; Chinta et al., 2018; Kritsilis et al., 2018), and pathological hallmarks of AD and PD, such as Aβ, tau, and α-synuclein, were reported to induce senescence in in vitro or in vivo models (Verma et al., 2021; Liu, 2022).