BDNF and coronary artery disorder: Manni et al. also found that nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) may be related to the pathogenesis of CAD, and the changes in the levels of these two neurotrophins are related to inflammation, so NGF and BDNF may also be potential targets for colchicine in the treatment of CAD (Manni et al., 2005).