NR4A1 and neoplasm: Nur77 was also found to contribute to pathological inflammatory responses in diseases such as atherosclerosis, obesity, diabetes, arthritis, inflammatory bowel disease, acute liver inflammation, neuroinflammation, tumor inflammation, and respiratory diseases (Hanna et al., 2012; Wu et al., 2016; Li et al., 2020; Li et al., 2022; Ahuja et al., 2023).