MAPT and nevus comedonicus syndrome: In 2021, the second consensus definition of CTE-NC was published (9), and the defining characteristic of CTE-NC was narrowed in an attempt to more clearly differentiate CTE-NC from age-related tau astrogliopathy (ARTAG) (10)—with more emphasis placed on p-tau aggregates in deeper cortical layers, not restricted to superficial or subpial regions.