Our results showed that mutations of four genes (EGR2, FBXW7, RPS15, and FOXO1) were directly related to shorter TFS, and six genes (NOTCH1, ATM, GNA12, KDM6A, KMT2A, and FBXW7) were linked to four clinical factors associated with shorter TFS, including CLL-IPI, del(11q), splenomegaly, and newly diagnosed platelets <100 × 109/L. The gene discussed is FBXW7; the disease is Splenomegaly.