It has also been proposed that the TAG-lowering effect of n-3 PUFAs is best explained by an effect on the NEFA pool (187), which, at least in obesity, may partly occur via suppression of adipose tissue inflammation and thereby reducing intracellular lipolysis in adipocytes mediated by adipose triacylglycerol lipase and hormone-sensitive lipase. This evidence concerns the gene LIPE and obesity due to melanocortin 4 receptor deficiency.