This finding was supported by a strong correlation between IL10 and SIGLEC1 expression in primary tumors from breast cancer patients using the TCGA data base in R2 (r2.amc.nl) (R=0.63; P=1.54e-122) (Figure 6D), but not by the IL10 V-PLEX protein analysis data due to low detection levels (N=3; Supplementary Table 1), a finding that also could be explained by natural polymorphism in the human IL10 gene promoter (46). This evidence concerns the gene IL10 and breast carcinoma.