The non-psychoactive cannabis constituent Cannabichromeene reduces NO, IL-10, and INFγ levels in LPS- activated peritoneal macrophages depending on TRPA1 activation (66).TRPA1 is upregulated in colitis, and its activation exerts a protective effect by reducing the expression of cytokines IL-1β and chemokine MCP-1 (67). The gene discussed is TRPA1; the disease is colitis.