Early TRPV4 regulates intracellular pathogens by regulating phagosome acidification and maturation, and late TRPV4 promotes neutrophil responses to proinflammatory stimuli, reactive oxygen species production, adhesion, and chemotaxis (80).The TRP channels modulated Ca2+ signaling pathway could be potential therapeutic targets in respiratory disease. The gene discussed is TRPV4; the disease is respiratory system disorder.