Voutsadakis et al., used publicly available genomic cohorts (The Cancer Genome Atlas, the MSK-IMPACT study, the pancreatic cancer sub-cohort of a pan-cancer study from China, and the pancreatic cancer cohort from the American Association for Cancer Research project GENIE), along with cBioportal and OncoKB knowledgebase, to characterize the GAs that occur in PDA without commonly seen alterations such as KRAS, TP53, CDKN2A and SMAD4. This evidence concerns the gene SMAD4 and familial pancreatic carcinoma.