Therefore, increasing the sensitivity of osteosarcoma cells to cisplatin is very meaningful for the treatment of osteosarcoma, and it was found that miR-181a-5p (55), miR-214 (58), miR-221 (94), miR-128 (177) and other microRNAs related to the PI3K/AKT pathway in osteosarcoma cells They are pro-oncogenic factors, and by inhibiting their expression, the sensitivity of osteosarcoma cells to CDDP can be improved. This evidence concerns the gene AKT1 and osteosarcoma.