significantly inhibited the phosphorylation of AKT by sodium cantharidininate (SC) without inhibiting mTOR, JNK or p38, and inhibition of AKT phosphorylation decreased the expression of CDK4, CDK6 and cyclin D1, which induced G0/G1 phase block in MG-63 cells that further inhibited the proliferation of osteosarcoma cells (Figure 2D) (104). This evidence concerns the gene MAPK8 and osteosarcoma.