While miR-183-5p (164), miR-133b (167), miR-615 (59), miR-499a-5p (175), miR-29c -3p (178), miR-520c-3p (179), miR-195-5p (181), miR 141-3p (174) and other PI3K/AKT pathway-related microRNAs all showed low expression in osteosarcoma, and their expression was negatively correlated with clinical stage and TNM stage. Here, PIK3CA is linked to osteosarcoma.