PIK3CD and osteosarcoma: It was found that by overexpressing miR-101 and miR-139 (Figure 6D) can downregulate rock1 while causing PI3K/AKT and JAK/STAT signaling pathway inactivation, ultimately leading to the malignant behavior of osteosarcoma cells can be partially suppressed, including biological behaviors such as abnormal proliferation, migration and invasion (191, 197).