MiR-134, miR-497 and miR-410 were found to be lowly expressed in osteosarcoma cells, and functionally microRNA-134, miR-497 and miR-410 could lead to reduced expression of VEGF and VEGFR1, thus inhibiting the PI3K/AKT pathway leading to osteosarcoma angiogenesis, proliferation, migration, invasion, cell growth, and drug resistance (Figure 6B) (183, 200, 206). This evidence concerns the gene AKT1 and osteosarcoma.