Further investigating the role of TRAIL in cholangiocarcinoma tumor tissue, there was an indication of a positive prognostic value in tissue expression of both TRAIL-R2/TNFRSF10B and TRAIL-R4/TNFRSF10D with a significant association to disease-free survival in the cohort from Ahn et al. The gene discussed is TNFSF10; the disease is neoplasm.