AFP and hepatitis B virus infection: Three datasets represented diverse iCCA cohorts, from Japan (23) (Nakamura et al, RNA sequencing, n=112, hepatitis B 5%, hepatitis C 3%), France (24) (Job et al, n=72, microarray, hepatitis B 5%, hepatitis C 3%) and China (25) (Dong et al, RNA sequencing, n=224, alpha-fetoprotein [AFP] ≥21ng/ml 10%, hepatitis B 27%).