However, in data from three cohorts, tumor tissue expression of TRAIL-R4/TNFRSF10D showed a similar prognostic influence as expression of the agonistic TRAIL receptors TRAIL-R1/TNFRSF10A and TRAIL-R2/TNFRSF10B: a congruent positive association to disease-free survival or overall survival in two cohorts, and to negative survival in one cohort. The gene discussed is TNFRSF10D; the disease is neoplasm.