This recognition is not only supported by extensive biomedical research in animal models of hypertension, but also by numerous clinical trials using the inhibitors of renin, angiotensin-converting enzyme (ACE), or type 1 angiotensin II (Ang II) receptor (AT1) or aldosterone receptor blockers to treat hypertension in human subjects (1–4). The gene discussed is ACE; the disease is Hypertension.