In female PT-Nhe3−/− mice, however, systolic, diastolic, and mean arterial blood pressure responses to Ang II began to decrease 4 days after Ang II infusion, suggesting that estrogen (and/or other female hormones) may contribute to these sex differences in Ang II-induced hypertension in this mutant mouse model (Figure 5). This evidence concerns the gene AGT and Hypertension.