The potential mechanisms responsible for this outcome are complex and varied, including effects on the central nervous system, inhibition of the vagal, excitation of the sympathetic nerve, activation of the renin-angiotensin-aldosterone system, increased cortisol secretion, insulin resistance and impaired glucose tolerance, oxidative stress, and impaired endothelial function (35, 36). The gene discussed is REN; the disease is Impaired glucose tolerance.