PIN4 and hepatocellular carcinoma: HCC and other cancer cells express high levels of Par14/Par17 protein (Saeed et al., 2019) (Figure 6C, fourth panel; lane 1) and Par14/Par17 bind to both HBc and the core particle to increase their stability (Saeed et al., 2021); in addition, Par14 might compensate for a lack of Pin1 (Uchida et al., 2003).