Our previous research proved that MT01 could promote osteoblast maturation and activation in rats, reduce rat alveolar bone absorption caused by periodontitis, regulate the expression levels of osteogenesis-related factors such as intracellular runt-related transcription factor 2 (Runx-2), collagen type I (COL I), and osteoprotegerin (OPG), and promote bone marrow mesenchymal stem cell differentiating into osteoblasts. This evidence concerns the gene TNFRSF11B and periodontitis.