YTHDF2 and esophageal squamous cell carcinoma: Cui et al. (2021) found that LINC00022, which is demethylated by the m6A eraser FTO, promotes tumor growth of ESCC. LINC00022 is upregulated in primary ESCC samples and associated with poor outcomes for ESCC patients. In ESCC cells, LINC00022 interacts with P21 protein and enhances ubiquitination-mediated degradation of P21. The m6A eraser FTO reduces m6A methylation levels of LINC00022 and results in inhibited LINC00022 decay via the m6A reader YTHDF2. Therefore, over-expressed FTO drives LINC00022-dependent ESCC cell proliferation in vitro and in vivo.