10 KEGG items including cytokine-cytokine receptor interaction, chemokine signaling pathway, T cell receptor signaling pathway, leukocyte transendothelial migration, toll-like receptor signaling pathway, TGF-β signaling pathway, JAK-STAT signaling pathway, mTOR signaling pathway, MAPK signaling pathway, pathway in cancer were significantly enriched in the increased expression phenotypes of TMEM200A (Table 4) (Figs. 5 and S1). The gene discussed is SOAT1; the disease is cancer.