Multivariate analysis showed that TMEM200A (HR = 1.064; 95% CI [1.013–1.117]; P = 0.013), age (HR = 1.037; 95% CI [1.016–1.058]; P = 0.000) and gender (HR = 1.599; 95% CI [1.041–2.457]; P = 0.032) were independently associated with overall survival in GC (Table 3) (Fig. 4). The gene discussed is TMEM200A; the disease is gastric cancer.