In several cancer types, differential harmonization of gene expression of TMEMs have been found, such as breast cancer (TMEM17) (Zhao et al., 2018), lung cancer (TMEM116) (Zhang et al., 2021a), cervical cancer (TMEM48) (Jiang et al., 2021), gastric cancer (TMEM45B) (Shen et al., 2018), colorectal cancer (TMEM180) (Shiraishi et al., 2021), glioblastoma multiforme (TMEM39A) (Tran et al., 2017), hepatocellular carcinoma (TMEM106C) (Duan et al., 2021), osteosarcoma (TMEM45B) (Li et al., 2017). The gene discussed is TMEM45B; the disease is osteosarcoma.