In an experimental study by Bakshi et al. (2022), it was mentioned that crocin inhibited TNF- α, NF- κB and VEGF pathways in colon cancer cells (HT-29 and Caco-2) in a dose-dependent manner, thereby inhibiting migration, invasion and angiogenesis of colon cancer cells. Here, VEGFA is linked to malignant colon neoplasm.