TLR4 and irritable bowel syndrome: In the control group, loss of H-W equilibrium was detected for SNPs -819T/C (rs1800871), -1082A/G (rs1800896) of the IL10 gene, Asp299Gly (rs4986790) of the TLR4 gene, 8202A/G (rs11697325) of the MMP-9 gene, not allowing us to analyze SNP data on the association of the allele frequency with the development of IBS and ADPC concomitant with IBS (Table 1).