The general model of heredity validated the relationship of frequency of SNP genotypes of IL10-592C/A (rs1800872), TLR4 Thr399ile (rs4986791), and TLR2 Arg753Gln (rs5743708) genes with the tendency to emergence of IBS that is in concordance with the data of the multiplicative model of heredity. This evidence concerns the gene TLR2 and irritable bowel syndrome.