TLR2 and irritable bowel syndrome: Moreover, from the TLR2 gene Arg753Gln (rs5743708) polymorphism, the strongest genetic relationship was also defined in patients with ADPC concomitant with IBS: AG genotype (χ2 = 12.78, P < .002, OR = 10.42, 95% CI: 2.28-47.61), which confirmed the special role of this polymorphic variation in the susceptibility to these diseases, which is crucial for early diagnosis of adenomatous polyps as a precancerous disease.