TLR2 and irritable bowel syndrome: In addition, the AA genotype of the TLR2 gene Arg753Gln (rs5743708) polymorphism was significantly less frequently determined in patients of both groups, which confirms the protective effect of the A allele in such patients, and the appearance of G allele can be considered as the prognostic marker of possible formation of adenomatous polyps concomitant with IBS.