TLR4 and irritable bowel syndrome: Therefore, timely study of the SNPs of the IL10-1082A/G (rs1800896), TLR2 Arg753Gln (rs5743708), TLR4 Asp299Gly (rs4986790), and MMP-9-8202A/G (rs11697325) genes in patients with IBS will promote prediction of the course of the disease, identify the tendency to the formation of ADPC concomitant with IBS and further prevention of disease progression.