The development of the IBS was associated with the C alleles of the IL10 gene-592C/A (rs1800872) and TLR4 gene Thr399ile (rs4986791) polymorphisms, the frequency of the TT genotype of the IL10 gene-819T/C (rs1800871) and GG genotype of the IL10 gene-1082A/G (rs1800896) polymorphisms and heterozygous CT genotype of the IL1 gene-511C/T (rs16944) polymorphism. This evidence concerns the gene TLR4 and irritable bowel syndrome.