Confirmation of the similarity of the mechanisms of influence on IBS and ADPC concomitant with IBS20,25,28 is the detection of an increased frequency of the AA genotype of the TLR4 gene Asp299Gly (rs4986790) polymorphism and a decrease of the heterozygous variation in the SNP, compared to intact subjects (P < .01). The gene discussed is TLR4; the disease is irritable bowel syndrome.