In contrast to group 1, in patients with ADPC and IBS, we determined a pronounced association of the disease with AA genotype of the IL10 gene -1082A/G (rs1800896) polymorphism (χ2 = 33.97, P < 4.0E-8, OR = 15, 50, 95% CI: 5.05-47.60), as well as the influence on the development of the disease was detected from the TT genotype of the IL1β gene-31C/T (rs1143627) polymorphism (χ2 = 7.05, P < .03, OR = 3.00, 95% CI: 1.14-7.87). This evidence concerns the gene IL1B and irritable bowel syndrome.