The analysis of the SNP in the ММP-9 gene-8202A/G (rs11697325), TLR2 gene Arg753Gln (rs5743708), TLR4 gene Thr399ile (rs4986791), and Asp299Gly (rs4986790) was made to identify a possible hereditary predisposition to dysregulatory changes in the reparative capacity of the CM, disorders in the microbiota in patients with IBS and ADPC concomitant with IBS (Figure 2). The gene discussed is TLR2; the disease is irritable bowel syndrome.