The similarity of the detected changes determined the possibility of the relationship between these pathologies and the possible protective effect of SNP of TLR, which confirms the data of other researchers.17,22 In patients with IBS and intact subjects, a heterozygous variation of the AG genotype of the MMP-9 gene-8202A/G (rs11697325) (P < .05) was significantly more frequently detected, compared to ADPC concomitant with IBS, which can possibly be the marker of susceptibility to disruptive reparative properties of the CM. Here, MMP9 is linked to irritable bowel syndrome.