The findings of the study showed that in patients of group 1, the association of the emergence of IBS was detected for SNPs: with the frequency of the C allele -592C/A (rs1800872) (IL10, χ2 = 7.78, P < .005), C allele Thr399ile (rs4986791) (TLR4, χ2 = 7.75, P < .005), G allele Arg753Gln (rs5743708) (TLR2, χ2 = 14.89, P < .0001). The gene discussed is TLR4; the disease is irritable bowel syndrome.