Detection of genetic risk for patients of both groups, associated with the frequency of the G allele, SNP of the TLR2 gene Arg753Gln (rs5743708), confirms the possible effect of this polymorphic variation on the emergence of ADPC concomitant with IBS and is a risk factor for neoplastic alterations in patients with FBD and can be a prognostic marker in patients with IBS. This evidence concerns the gene TLR2 and irritable bowel syndrome.