TLR4 and irritable bowel syndrome: The analysis of the SNP in the ММP-9 gene-8202A/G (rs11697325), TLR2 gene Arg753Gln (rs5743708), TLR4 gene Thr399ile (rs4986791), and Asp299Gly (rs4986790) was made to identify a possible hereditary predisposition to dysregulatory changes in the reparative capacity of the CM, disorders in the microbiota in patients with IBS and ADPC concomitant with IBS (Figure 2).