MMP9 and irritable bowel syndrome: The genetic analysis of MMP-9 showed that in patients of group 2, AG genotype-8202A/G (rs11697325) polymorphism was detected significantly less frequently (29 (45.3%) patients) (P < .05), compared to group 1 and control group, which may determine the value of this polymorphism in the emergence of ADPC concomitant with IBS, due to the modifying effect on the reparative and inflammatory processes in the CM.