Our results revealed a positive feedback loop between LINC02568 and ERα that amplifies the estrogen signaling in ER+ breast cancer, in which estrogen/ERα activates the expression of LINC02568, and LINC02568 in turn regulates the expression of ERα through a ceRNA mechanism to boost estrogen/ERα‐mediated gene transcriptional program (Figure 7). This evidence concerns the gene ESR1 and breast cancer.