However, the characterization, functions, and mechanisms of these lncRNAs have not been fully elucidated yet.[16, 46, 47, 48, 49] In this study, we identified an estrogen‐induced lncRNA, LINC02568, which is clinically relevant in ER+ breast cancer and functionally important for the malignant phenotypes and tamoxifen resistance in ER+ breast cancer cells. The gene discussed is ESR1; the disease is breast cancer.