In CM patients, MV abundance has been correlated with the depth of coma and degree of thrombocytopenia18 Cytokine stimulated brain endothelial cell MVs can interact with T cells in an ICAM-1- and VCAM-1-dependent fashion14 and infected erythrocyte MVs can carry functional miRNA that can be internalised by endothelial cells.14 The gene discussed is VCAM1; the disease is cutaneous mastocytosis.